Polynucleotides (PDRN/PN)
PDRN · PN · polidesossiribonucleotide
Skin biostimulation and regeneration: hydration, skin quality, support to healing.
Grade
Under review
- Class
- Regenerative
- Primary use
- Skin biostimulation
- Evidence strength
- medium
- Last reviewed
- 2026-06-01
Review in progress: the grade will be assigned once the source analysis is complete.
The claim
Skin biostimulation and regeneration: hydration, skin quality, support to healing.
What the evidence says
Several clinical studies (often small, sometimes industry-sponsored) report improvements in skin elasticity and hydration after injectable treatments. Heterogeneous protocols and endpoints; larger independent RCTs are needed.
Key studies
- [1]
Literature on polynucleotides and skin (PubMed search) · review
Starting point for the ongoing review; the grade will be assigned at closure.
PubMed ↗
Mechanism
DNA fragments thought to act as adenosine A2A receptor agonists, stimulating fibroblasts, collagen synthesis and angiogenesis; a local nucleotide 'salvage' effect.
Safety
Generally favourable profile in aesthetic use; transient local events (erythema, swelling). Medical procedure: professionals only.
Dosage context
Injectable protocols vary by concentration and number of sessions; no universally validated standard in independent literature.
From the field
It's one of the most marketed molecules in aesthetics. We're closing the review of independent sources before assigning a grade: on principle we don't publish a letter we can't defend with the studies.