Hyaluronic acid

hyaluronic acid · hyaluronan · sodium hyaluronate

The skin- and joint-hydrating molecule used topically, orally and as a dermal filler.

TipoSupplement / topical / injectable

Il voto risponde a: What does the human evidence support for: Skin hydration & joint comfort?

Grado

Limitata

Il voto misura la qualità dell'evidenza, non è un consiglio ad assumere o acquistare.

Classe: Glycosaminoglycan
Uso principale: Skin hydration & joint comfort
Forza evidenza: medium
Ultima revisione: 2026-07-01

In sintesi

Well established for what it physically does — holding water — with decent evidence for skin hydration (topical/oral) and injectable use. As an ingested 'anti-aging' cure its systemic claims are more modest than the marketing.

Cosa dice l'evidenza

Hyaluronic acid is a natural component of skin and joint tissue that binds large amounts of water. The evidence splits by route: topical and injectable (dermal fillers, some osteoarthritis injections) use is well established for hydration and volume; oral supplementation has a growing set of small trials suggesting improved skin hydration and possibly joint comfort, though absorption and mechanism of ingested HA are debated. There is no systemic longevity evidence. Grade C: real, route-dependent cosmetic and joint benefits, not a longevity intervention.

Studi chiave

[1]
Oral hyaluronic acid and skin hydration · RCT
Small improvements in skin hydration/elasticity.
Apri su PubMed ↗
[2]
Hyaluronic acid injections for knee osteoarthritis · meta-analysis
Debated, modest benefit for joint symptoms.
Apri su PubMed ↗
[3]
Hyaluronic acid biology (review) · review
Background on its hydration and structural roles.
Apri su PubMed ↗

Vedi tutti gli studi su PubMed ↗

Meccanismo

A glycosaminoglycan that retains water to maintain tissue hydration and viscoelasticity; ingested HA is broken down and may act partly by signalling rather than direct incorporation.

Sicurezza

Topical and oral use are very well tolerated. Injectable procedures (fillers, intra-articular) are medical acts with procedure-related risks and should be done by professionals.

Contesto dosaggio

Oral trials commonly use ~120–240 mg/day over 8–12 weeks. Topical concentration and molecular weight affect performance; injectable use follows clinical protocols.

Esempi di applicazione

Applied topically in a serum on damp skin, then sealed with moisturiser.
Also taken orally (~120–240 mg/day) for skin hydration in trials.
Injectable use (fillers) is a medical procedure, professionals only.

Nota dal campo

Hyaluronic acid is a rare supplement where the physical mechanism is undeniable — it's just that 'holds water in skin' is a cosmetic claim, not a longevity one. Grade C, and route matters a lot.

Molecole correlate

Collagen peptidesC Polynucleotides (PDRN/PN)F

Come assegniamo i gradi → Metodo