Spermidine
spermidine
A polyamine that induces autophagy and may support longevity.
Grade
B
Moderate
- Class
- Autophagy
- Primary use
- Autophagy induction
- Evidence strength
- medium
- Last reviewed
- 2025-09-01
The claim
A polyamine that induces autophagy and may support longevity.
What the evidence says
Observational data and pilot trials suggest effects on autophagy and cognitive markers; larger RCTs are needed.
Key studies
- [1]
Spermidine and autophagy/longevity (PubMed) · review
Positive signals, evidence still building.
PubMed ↗
Mechanism
Autophagy induction via inhibition of acetyltransferases; effects on mitophagy and proteostasis.
Safety
Present in the diet; good tolerability at dietary doses.
Dosage context
Supplementation studied ~1–6 mg/day; often from wheat-germ extract.
From the field
Among the polyamines, the one with the most promising human base.