Spermidine
spermidine
A polyamine that induces autophagy and may support longevity.
Grado
B
Moderata
- Classe
- Autophagy
- Uso principale
- Autophagy induction
- Forza evidenza
- medium
- Ultima revisione
- 2025-09-01
Cosa promette
A polyamine that induces autophagy and may support longevity.
Cosa dice l'evidenza
Observational data and pilot trials suggest effects on autophagy and cognitive markers; larger RCTs are needed.
Studi chiave
- [1]
Spermidine and autophagy/longevity (PubMed) · review
Positive signals, evidence still building.
PubMed ↗
Meccanismo
Autophagy induction via inhibition of acetyltransferases; effects on mitophagy and proteostasis.
Sicurezza
Present in the diet; good tolerability at dietary doses.
Contesto dosaggio
Supplementation studied ~1–6 mg/day; often from wheat-germ extract.
Nota dal campo
Among the polyamines, the one with the most promising human base.