GlyNAC (glycine + NAC)

GlyNAC · glycine NAC · glycine and N-acetylcysteine

A glycine + N-acetylcysteine combination studied to restore glutathione and mitochondrial function with age.

TipoSupplement / dietary

Il voto risponde a: What does the human evidence support for: Glutathione & mitochondrial support?

Grado

Limitata

Il voto misura la qualità dell'evidenza, non è un consiglio ad assumere o acquistare.

Classe: Antioxidant / precursor
Uso principale: Glutathione & mitochondrial support
Forza evidenza: low
Ultima revisione: 2026-07-01

In sintesi

Intriguing early trials from a single research group show broad improvements in older adults — but the studies are small and largely unreplicated. Promising, not yet proven.

Cosa dice l'evidenza

GlyNAC pairs the two rate-limiting building blocks of glutathione. A series of small trials (predominantly from one group) reports improvements in glutathione levels, oxidative stress, mitochondrial function, insulin sensitivity, strength and even some aging biomarkers in older adults. That breadth is exciting — and exactly why independent replication matters before drawing firm conclusions. The trials are small, some open-label, and concentrated in one lab. Grade C reflects real promise held back by limited, not-yet-replicated evidence.

Studi chiave

[1]
GlyNAC supplementation in older adults (trials) · RCT / pilot
Broad marker improvements — small samples, mostly one group.
Apri su PubMed ↗
[2]
GlyNAC and oxidative stress / aging hallmarks · review
Mechanistic case across several aging hallmarks.
Apri su PubMed ↗
[3]
Glutathione decline with age (review) · review
Rationale for restoring glutathione in older adults.
Apri su PubMed ↗

Vedi tutti gli studi su PubMed ↗

Meccanismo

Supplies glycine and cysteine (via NAC) to raise cellular glutathione, aiming to lower oxidative stress and restore mitochondrial function that declines with age.

Sicurezza

Both components are well tolerated individually; the combination has been safe in the trials reported so far, over months rather than years.

Contesto dosaggio

Studied at weight-based doses of both amino acids under trial conditions. There is no standardised over-the-counter GlyNAC dose, and products vary widely.

Esempi di applicazione

Used as the glycine + NAC pair studied in older adults.
Dosing follows trial protocols; over-the-counter products vary.
Promising but not independently replicated — treat as experimental.

Nota dal campo

GlyNAC produces the most impressive-sounding results of any supplement here — and the thinnest independent replication. We hold it at C until other labs reproduce it, however good the story sounds.

Molecole correlate

GlycineC N-Acetylcysteine (NAC)C

Come assegniamo i gradi → Metodo