Metformin
metformin
A biguanide with metabolic effects and a hypothesised geroprotective action.
Grado
B
Moderata
- Classe
- Glucose metabolism
- Uso principale
- Insulin sensitivity / metabolism
- Forza evidenza
- medium
- Ultima revisione
- 2025-09-01
Cosa promette
A biguanide with metabolic effects and a hypothesised geroprotective action.
Cosa dice l'evidenza
Solid in diabetes; the 'anti-aging' hypothesis in non-diabetics is the subject of the TAME trial, not yet concluded. Geroprotective evidence in humans is not demonstrated.
Studi chiave
- [1]
Meccanismo
AMPK activation, reduced hepatic gluconeogenesis; hypotheses on mTOR and inflammation.
Sicurezza
Prescription drug, known profile; common GI upset, rare lactic acidosis.
Contesto dosaggio
Clinical dosing for diabetes; no validated longevity protocol.
Nota dal campo
We wait for TAME before moving the grade: today the human geroprotective proof isn't there.