Rapamycin
rapamycin · sirolimus
mTOR inhibitor with the strongest evidence of lifespan extension in animal models.
Grado
A
Forte
- Classe
- mTOR / Autophagy
- Uso principale
- mTOR inhibition
- Forza evidenza
- high
- Ultima revisione
- 2025-09-01
Cosa promette
mTOR inhibitor with the strongest evidence of lifespan extension in animal models.
Cosa dice l'evidenza
Robust, consistent preclinical evidence across species. In humans: a drug with defined clinical indications; off-label 'longevity' use is experimental and must be managed only with a physician.
Studi chiave
- [1]
Rapamycin and lifespan extension (PubMed) · review
Robust lifespan extension in animal models.
PubMed ↗
Meccanismo
Inhibition of the mTORC1 complex, with effects on autophagy, proteostasis and senescence.
Sicurezza
Prescription drug with known adverse effects (immunosuppression, metabolic effects). It is not a supplement.
Contesto dosaggio
Intermittent regimens are studied in research; no approved longevity protocol.
Nota dal campo
Grade A for the strength of preclinical evidence — not an invitation to use: it's a drug, not a supplement.