Resveratrol
resveratrol · trans-resveratrol
An 'anti-aging' polyphenol claimed to activate sirtuins.
Grade
C
Limited
- Class
- Antioxidants
- Primary use
- Sirtuin / antioxidant activity
- Evidence strength
- low
- Last reviewed
- 2025-09-01
The claim
An 'anti-aging' polyphenol claimed to activate sirtuins.
What the evidence says
Strong preclinical interest, but human trials are inconsistent and limited by poor bioavailability. Clinical benefits are not consistent.
Key studies
- [1]
Mechanism
Modulation of SIRT1 and antioxidant pathways; in vivo the effect is blunted by rapid metabolism.
Safety
Generally well tolerated at moderate doses; possible interactions at high doses.
Dosage context
Very heterogeneous studies (150 mg–1 g/day). No consensus.
From the field
A classic case where preclinical enthusiasm did not translate to humans.