Resveratrol
resveratrol · trans-resveratrol
An 'anti-aging' polyphenol claimed to activate sirtuins.
Grado
C
Limitata
- Classe
- Antioxidants
- Uso principale
- Sirtuin / antioxidant activity
- Forza evidenza
- low
- Ultima revisione
- 2025-09-01
Cosa promette
An 'anti-aging' polyphenol claimed to activate sirtuins.
Cosa dice l'evidenza
Strong preclinical interest, but human trials are inconsistent and limited by poor bioavailability. Clinical benefits are not consistent.
Studi chiave
- [1]
Meccanismo
Modulation of SIRT1 and antioxidant pathways; in vivo the effect is blunted by rapid metabolism.
Sicurezza
Generally well tolerated at moderate doses; possible interactions at high doses.
Contesto dosaggio
Very heterogeneous studies (150 mg–1 g/day). No consensus.
Nota dal campo
A classic case where preclinical enthusiasm did not translate to humans.