TMG (Betaine)
TMG · trimethylglycine · betaine · betaine anhydrous
A methyl donor used to lower homocysteine and often paired with NMN/NR.
TipoSupplement / dietary
Il voto risponde a: What does the human evidence support for: Methylation & homocysteine support?
Grado
C
Limitata
Il voto misura la qualità dell'evidenza, non è un consiglio ad assumere o acquistare.
- Classe
- Methyl donor
- Uso principale
- Methylation & homocysteine support
- Forza evidenza
- medium
- Ultima revisione
- 2026-07-01
In sintesi
Reliably lowers homocysteine and has some sports-performance data — but whether that translates to longevity, or is even needed alongside NAD boosters, is unproven.
Cosa dice l'evidenza
Betaine (trimethylglycine) is a well-established methyl donor: it dependably lowers blood homocysteine, and there is reasonable evidence for small strength/power benefits in athletes. Its popularity in longevity stacks comes from a theory that NAD⁺ precursors like NMN consume methyl groups, so TMG 'replaces' them — a plausible idea that hasn't actually been shown to matter for outcomes in humans. High-dose betaine can also raise LDL/total cholesterol. Grade C: proven biochemical effect (homocysteine), unproven longevity payoff, with a lipid caveat.
Studi chiave
- [1]
- [2]
- [3]
Meccanismo
Donates methyl groups to convert homocysteine back to methionine (an alternative to the folate/B12 pathway), supporting methylation reactions throughout the body.
Sicurezza
Generally well tolerated; GI upset at higher doses. Notably, high-dose betaine has raised total and LDL cholesterol in some trials — relevant given the cardiovascular framing. Not a purely 'free' addition.
Contesto dosaggio
Homocysteine/performance trials use ~1.5–6 g/day; longevity-stack use is often ~500–1000 mg to 'offset' NAD-precursor methylation — a dose based on theory, not outcome data.
Esempi di applicazione
- Taken ~500–1000 mg to 'offset' NAD-precursor methylation (a theory).
- Or ~1.5–6 g/day where homocysteine lowering is the goal.
- Watched for a possible LDL rise at higher doses.
Nota dal campo
TMG is sold as the automatic partner to NMN. The homocysteine effect is real; the 'you must take it with your NAD booster' claim is theory, and the LDL signal is the part that gets left out. Grade C.